Artikkel: Immunrespons av genmodifisert mais

21.11.2008

En studie publisert i den vitenskaplige journalen “Argicultural and Food Chemistry” har sett på effektene på sårbare mus som ble foret med genmodifisert mais. Studien viser blant annet forandringer i immunofenotypen til musenes milt, sirkulerende lymfocytter og tarm.

Abstrakt:

J. Agric. Food Chem.

Intestinal and Peripheral Immune Response to MON810 Maize Ingestion in Weaning and Old Mice

^{ALBERTO FINAMORE, MARIANNA ROSELLI, SERENA BRITTI, GIOVANNI MONASTRA, ROBERTO AMBRA, AIDA TURRINI, AND ELENA MENGHERI*}

^{Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Via Ardeatina 546, 00178 Roma, Italy}

This study evaluated the gut and peripheral immune response to genetically modified (GM) maize in mice in vulnerable conditions. Weaning and old mice were fed a diet containing MON810 or its parental control maize or a pellet diet containing a GM-free maize for 30 and 90 days. The immunophenotype of intestinal intraepithelial, spleen, and blood lymphocytes of control maize fed mice was similar to
that of pellet fed mice. As compared to control maize, MON810 maize induced alterations in the percentage of T and B cells and of CD4+, CD8+, γδT, and R_T subpopulations of weaning and old mice fed for 30 or 90 days, respectively, at the gut and peripheral sites. An increase of serum IL-6, IL-13, IL-12p70, and MIP-1_ after MON810 feeding was also found. These results suggest the importance of the gut and peripheral immune response to GM crop ingestion as well as the age of
the consumer in the GMO safety evaluation.
 

Arikkelen in sin helhet.